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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
13.64
Human Site:
S116
Identified Species:
20
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
S116
N
P
E
E
E
L
A
S
K
Q
K
N
E
E
S
Chimpanzee
Pan troglodytes
XP_525364
403
45791
S116
N
P
E
E
E
L
A
S
K
Q
K
N
E
E
S
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
T183
Q
P
A
G
E
A
V
T
A
A
N
Q
T
A
Q
Dog
Lupus familis
XP_853397
405
45606
T117
N
S
E
K
E
L
A
T
K
Q
K
N
E
E
S
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
K116
Q
K
T
E
D
T
K
K
R
Q
W
T
L
E
D
Rat
Rattus norvegicus
P59241
397
44856
S116
S
I
Q
K
T
E
D
S
K
K
R
Q
W
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
A49
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
Chicken
Gallus gallus
XP_425725
409
46456
S120
A
K
S
S
E
A
D
S
V
S
K
Q
K
N
E
Frog
Xenopus laevis
Q91819
408
46443
D118
M
E
K
K
G
S
T
D
Q
G
K
T
L
A
V
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
N66
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
H74
V
Y
L
A
R
E
R
H
S
H
Y
L
V
A
M
Honey Bee
Apis mellifera
XP_395732
327
37711
G73
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
Nematode Worm
Caenorhab. elegans
O01427
305
34731
T51
V
Y
L
A
R
T
K
T
G
H
F
H
V
A
I
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
L24
G
K
F
G
S
V
Y
L
A
R
E
K
Q
T
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
G28
I
G
K
P
L
G
R
G
K
F
G
H
V
Y
L
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
G113
L
G
K
K
L
G
K
G
K
F
G
K
V
Y
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
13.3
80
N.A.
20
13.3
N.A.
6.6
20
6.6
6.6
N.A.
0
13.3
0
0
P-Site Similarity:
100
100
20
93.3
N.A.
33.3
46.6
N.A.
33.3
26.6
26.6
26.6
N.A.
0
13.3
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
13
0
13
19
7
13
7
0
7
0
25
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
0
0
0
7
0
13
7
0
0
0
0
0
0
7
% D
% Glu:
0
7
19
19
32
13
0
0
0
7
7
0
19
32
7
% E
% Phe:
0
7
7
0
0
7
0
0
0
19
7
0
0
0
7
% F
% Gly:
7
25
7
19
7
19
7
19
7
7
19
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
13
0
13
0
0
0
% H
% Ile:
13
7
0
0
0
0
0
0
0
0
0
0
0
0
7
% I
% Lys:
7
19
25
25
7
0
25
7
44
7
38
13
7
7
7
% K
% Leu:
13
0
13
0
19
19
7
7
0
0
7
7
13
0
19
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
19
0
0
7
0
0
0
7
0
0
7
25
0
7
0
% N
% Pro:
0
19
0
13
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
13
0
7
0
0
0
0
0
7
25
0
25
7
0
7
% Q
% Arg:
0
0
7
0
13
0
13
0
13
7
7
0
7
0
7
% R
% Ser:
7
7
7
7
7
7
0
25
7
7
0
0
7
0
19
% S
% Thr:
0
0
7
0
7
13
7
19
0
0
0
13
7
13
0
% T
% Val:
13
0
0
0
7
7
7
0
13
0
0
0
32
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
7
0
7
0
0
% W
% Tyr:
0
13
0
0
0
7
7
0
0
7
7
0
0
19
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _